Decision-grade intelligence for clinical research
Powered by Engram's state-of-the-art AI reasoning systems, Engram Clinical analyzes protocols, budgets, CTAs, and billing artifacts to surface risk, inconsistencies, and opportunities that manual workflows miss.
Medical Coverage Analysis
Automatically classify procedures, detect payer conflicts, and generate audit-ready rationale. The MCA workbench processes 118 rows in 2.3 seconds with 98% automation.
| Visit | Procedure | Freq | Plan Hint | AI Proposal | Status |
|---|---|---|---|---|---|
| Cycle 3 Day 1 | Brain MRI 70553 | 1 | Plan: Sponsor | AI: Medicare | Conflict |
| Screening | Informed Consent NA | 1 | Plan: Sponsor | AI: Sponsor | Auto-classified |
| Screening | Physical Examination 99204 | 1 | Plan: Medicare | AI: Medicare | Auto-classified |
| Screening | 12-lead ECG 93000 | 1 | Plan: Sponsor | AI: Sponsor | Auto-classified |
| Cycle 1 Day 1 | Disease Assessment (CBC) 85025 | 1 | Plan: Medicare | AI: Medicare | Auto-classified |
| Cycle 1 Day 1 | Bone Marrow Aspirate 38220 | 1 | Plan: Sponsor | AI: Medicare | Conflict |
| Cycle 1 Day 1 | PK Blood Draw 36415 | 1 | Plan: Sponsor | AI: Sponsor | Auto-classified |
| Cycle 1 Day 8 | Vital Signs 99211 | 1 | Plan: Medicare | AI: Medicare | Needs review |
Brain MRI
70553 - Cycle 3 Day 1
AI detected a critical 4-way mismatch. While the CTA states Sponsor pays for all MRIs, the Budget only reimburses 2 occurrences. The Protocol requires 3 MRIs (Screening, C3D1, EOT). Since this is the 3rd MRI and exceeds the budgeted amount, and is standard of care for this indication, AI proposes Medicare coverage to avoid unreimbursed costs.
Model cross-referenced CMS coverage rules and site standard-of-care policies.
Built for clinical operations
Clinical research operates under strict regulatory constraints—21 CFR Part 11, ICH-GCP, SOC 2. Engram Clinical is purpose-built for this environment, with full audit trails, explainable AI decisions, and integration with clinical trial management systems.
Coverage Determination
Automated payer classification
| Procedure | Coverage | Status | Flags |
|---|---|---|---|
| CBC | Routine | Covered | None |
| MRI Brain | Research | Flagged | Conflict |
| ECG | Routine | Covered | None |
| CT Chest | Ambiguous | Review | Evidence needed |
| Labs Panel | Research | Not Covered | None |
Measurable impact
Engram Clinical is deployed with trial sponsors and CROs processing thousands of procedures monthly.
Ready to accelerate your clinical operations?
Schedule a demo to see how Engram Clinical can reduce manual review time and surface hidden risks in your protocols.